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Discoveries in the word of Human Genomics
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Apr

23

CRISPR one of the newest discoveries in the word of human genomics, is arming T-Cells to fight cancer

New advances in sequences and editing DNA are common occurrences in the field of genomics. Scientist are regularly seeking new ways to harness the power of the human genome to prevent, protect and cure the human body. The newest of those findings related to mapping the human genome is known as CRISPR (pronounced crisper) Clustered regularly interspaced short palindromic repeats (CRISPR) is one of the newest discoveries in the word of human genomics, and could hold the key to understand and preventing diseases. While mapping the human genome, scientist discovered CRISPRs, which are segments of prokaryotic DNA, and work as a key to unlock each segment in the overall sequence. CRISPR is quickly gaining ground in the field of genomics, its uses and potential for how it can be harness are exponential. One area where the CRISPR technology has shown the greatest potential is in the fight against cancer. From this discovery they have created tools that allow them to further unlock the human genome, one of these tools, CRISPR-Cas9. According to the National Human Genome Research Institute, CRISPR-Cas9 is a customizable tool that lets scientists cut and insert small pieces of DNA at precise areas along a DNA strand. This allows for scientist to control a particular trait in DNA. The CRISPR technology allows them to guide a Cas9 protein the desired gene, or segment of DNA, in a way that is specific, targeted and in real-time. Thus allowing for more precise study of the impact of changes or mutations in the genes or segments of the DNA sequences, and the overall impact of those changes on the cells and the organism. (https://bit.ly/2OwU2cC) A recent paper by Michel Sadelain, M.D., Ph.D., of Memorial Sloan Kettering Cancer Center, and his colleagues found CRISPR also has tremendous potential in cancer treatments as well. The team reported that in recent studies they had edited the T-cells to recognize and attack cancer cells that expressed certain a type of protein marker or antigen, in a way reprogramming the T-cells, the protectors cells in the blood system, to kill off any potentially harmful invading cells that carry the targeted antigen by producing a chimeric antigen receptor proteins (CARs). https://www.mskcc.org/press-releases/car-cells-more-powerful-when-built-crispr-msk-researchers-find The new discovery could provide doctors with a new, directed method of immunotherapy for the treatment of cancer. Dr. Sadelain, Director of the Center for Cell Engineering and the Gene Transfer and Gene Expression Laboratory at Memorial Sloan Kettering Cancer Center explained the importance of this type of cancer treatment. Stating that, “Cancer cells are relentless in their attempt to evade treatment, so we need CAR T-cells that can match and outlast them.” Going on to say that he and his team are egger to continue their work as their findings promising showing that “we may to harness the power of genome editing to give these ‘living therapies’ a built-in boost,” and lead to the genome-editing technology becoming the next generation of CAR T-cell therapy. https://www.mskcc.org/press-releases/car-cells-more-powerful-when-built-crispr-msk-researchers-find RESOURCES https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/questions-and-answers-about-crispr https://bit.ly/2OwU2cC https://www.mskcc.org/press-releases/car-cells-more-powerful-when-built-crispr-msk-researchers-find

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